| 8. Round | 07/09/2021 | Club Tijuana [Women] | - | Club León [Women] | 4:0 | ||||
| 9. Round | 12/09/2021 | CF Monterrey [Women] | - | Club Tijuana [Women] | 4:0 | ||||
| 10. Round | 28/09/2021 | UANL Tigres [Women] | - | Club Tijuana [Women] | 3:0 | ||||
| 14. Round | 01/11/2021 | Club Necaxa [Women] | - | Club Tijuana [Women] | 1:2 | ||||
| 15. Round | 09/11/2021 | Club Tijuana [Women] | - | Mazatlán FC [Women] | 5:0 | ||||
| 16. Round | 16/11/2021 | Club Tijuana [Women] | - | Cruz Azul [Women] | 4:1 | ||||
| 17. Round | 20/11/2021 | FC Juárez [Women] | - | Club Tijuana [Women] | 2:4 |
Mexico