| 4. Round | 28/08/2021 | SV Rödinghausen | - | VfB Homberg | 0:1 | ||||
| 5. Round | 04/09/2021 | VfB Homberg | - | Rot Weiss Ahlen | 1:2 | ||||
| 6. Round | 10/09/2021 | Rot-Weiss Essen | - | VfB Homberg | 3:0 | ||||
| 8. Round | 18/09/2021 | Wuppertaler SV | - | VfB Homberg | 3:1 |  |
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| 9. Round | 25/09/2021 | VfB Homberg | - | Fortuna Köln | 0:0 | ||||
| 10. Round | 02/10/2021 | Fortuna Düsseldorf II | - | VfB Homberg | 4:0 | ||||
| 7. Round | 06/10/2021 | VfB Homberg | - | SV 19 Straelen | 0:1 | |
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| 11. Round | 09/10/2021 | Bonner SC | - | VfB Homberg | 2:0 | ||||
| 15. Round | 06/11/2021 | Rot-Weiß Oberhausen | - | VfB Homberg | 3:1 | |
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| 16. Round | 13/11/2021 | VfB Homberg | - | KFC Uerdingen 05 | 1:1 | ||||
| 17. Round | 20/11/2021 | SC Wiedenbrück | - | VfB Homberg | 3:0 | ||||
| 18. Round | 27/11/2021 | VfB Homberg | - | 1. FC Köln II | 1:3 | |
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| 20. Round | 11/12/2021 | Bor. Mönchengladbach II | - | VfB Homberg | 2:0 | ||||
| 21. Round | 18/12/2021 | VfB Homberg | - | Sportfreunde Lotte | 1:2 |
Ghana