| 3. Round | 29/08/2021 | Lommel SK | - | KMSK Deinze | 2:2 | ||||
| 4. Round | 11/09/2021 | Excelsior Virton | - | Lommel SK | 2:1 | ||||
| 6. Round | 25/09/2021 | RWD Molenbeek | - | Lommel SK | 1:2 | ||||
| 7. Round | 01/10/2021 | KVC Westerlo | - | Lommel SK | 2:0 |  |
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| 10. Round | 31/10/2021 | Lommel SK | - | RWD Molenbeek | 2:3 | |
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| 11. Round | 05/11/2021 | Lommel SK | - | Excelsior Virton | 1:3 | ||||
| 12. Round | 21/11/2021 | KMSK Deinze | - | Lommel SK | 3:3 |  |
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| 13. Round | 27/11/2021 | Lommel SK | - | KVC Westerlo | 0:1 | |
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| 14. Round | 05/12/2021 | Lierse Kempenzonen | - | Lommel SK | 2:2 | |
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| 15. Round | 11/12/2021 | Royal Excel Mouscron | - | Lommel SK | 2:1 | |
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| 16. Round | 17/12/2021 | Lommel SK | - | Waasland-Beveren | 1:1 | ||||
| 17. Round | 21/01/2022 | RWD Molenbeek | - | Lommel SK | 2:0 | ||||
| 18. Round | 28/01/2022 | Lommel SK | - | Lierse Kempenzonen | 0:1 | ||||
| 19. Round | 06/02/2022 | KVC Westerlo | - | Lommel SK | 3:0 | |
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| 21. Round | 20/02/2022 | KMSK Deinze | - | Lommel SK | 1:1 | ||||
| 23. Round | 05/03/2022 | Lierse Kempenzonen | - | Lommel SK | 0:2 | ||||
| 27. Round | 08/04/2022 | Excelsior Virton | - | Lommel SK | 2:3 | ||||
| 28. Round | 16/04/2022 | Lommel SK | - | KMSK Deinze | 2:1 |
Iceland