| 1. Round | 16/07/2022 | NK Osijek | - | HNK Gorica | 2:1 | ||||
| 2. Round | 24/07/2022 | Lokomotiva Zagreb | - | NK Osijek | 2:1 |  |
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| 3. Round | 31/07/2022 | NK Osijek | - | Slaven Belupo | 0:0 | ||||
| 5. Round | 14/08/2022 | NK Osijek | - | NK Varaždin | 2:2 |  |
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| 6. Round | 20/08/2022 | Dinamo Zagreb | - | NK Osijek | 5:2 | |
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| 7. Round | 28/08/2022 | NK Osijek | - | Hajduk Split | 2:1 | ||||
| 8. Round | 03/09/2022 | NK Osijek | - | HNK Šibenik | 1:1 | |
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| 9. Round | 10/09/2022 | HNK Rijeka | - | NK Osijek | 0:3 | ||||
| 10. Round | 17/09/2022 | HNK Gorica | - | NK Osijek | 0:1 | ||||
| 11. Round | 01/10/2022 | NK Osijek | - | Lokomotiva Zagreb | 4:1 | |
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| 12. Round | 09/10/2022 | Slaven Belupo | - | NK Osijek | 0:4 | |
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| 13. Round | 15/10/2022 | NK Osijek | - | NK Istra 1961 | 2:0 | ||||
| 14. Round | 22/10/2022 | NK Varaždin | - | NK Osijek | 4:1 | |
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| 15. Round | 29/10/2022 | NK Osijek | - | Dinamo Zagreb | 1:0 | ||||
| 16. Round | 05/11/2022 | Hajduk Split | - | NK Osijek | 3:1 | ||||
| 17. Round | 13/11/2022 | HNK Šibenik | - | NK Osijek | 0:2 |
Hungary