| 1. Round | 11/01/2022 | Pumas UNAM | - | Deportivo Toluca | 5:0 | ||||
| 2. Round | 16/01/2022 | Deportivo Toluca | - | Santos Laguna | 3:1 |  |
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| 3. Round | 22/01/2022 | Mazatlán FC | - | Deportivo Toluca | 1:2 | |
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| 5. Round | 12/02/2022 | Atlético San Luis | - | Deportivo Toluca | 0:1 | ||||
| 6. Round | 21/02/2022 | Deportivo Toluca | - | Cruz Azul | 1:4 | ||||
| 7. Round | 25/02/2022 | Gallos Blancos | - | Deportivo Toluca | 1:1 | |
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| 9. Round | 05/03/2022 | Club Necaxa | - | Deportivo Toluca | 0:1 | ||||
| 11. Round | 20/03/2022 | CF América | - | Deportivo Toluca | 3:0 | |
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| 12. Round | 03/04/2022 | Deportivo Toluca | - | Puebla FC | 2:1 | ||||
| 4. Round | 07/04/2022 | Deportivo Toluca | - | CF Monterrey | 2:2 | |
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| 13. Round | 10/04/2022 | Deportivo Toluca | - | Deportivo Guadalajara | 1:1 | |
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| 14. Round | 17/04/2022 | UANL Tigres | - | Deportivo Toluca | 3:0 | ||||
| 15. Round | 20/04/2022 | Deportivo Toluca | - | FC Juárez | 0:1 | ||||
| 16. Round | 24/04/2022 | Deportivo Toluca | - | Atlas Guadalajara | 2:4 | ||||
| 17. Round | 02/05/2022 | Club León | - | Deportivo Toluca | 4:4 | |
Uruguay