| 1. Round | 02/07/2022 | Club Necaxa | - | Deportivo Toluca | 1:3 |  |
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| 2. Round | 10/07/2022 | Deportivo Toluca | - | Atlas Guadalajara | 3:2 | |
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| 3. Round | 14/07/2022 | CF América | - | Deportivo Toluca | 1:0 | ||||
| 4. Round | 23/07/2022 | Deportivo Toluca | - | Santos Laguna | 2:1 | |
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| 5. Round | 27/07/2022 | Club León | - | Deportivo Toluca | 0:1 | ||||
| 16. Round | 03/08/2022 | Deportivo Toluca | - | Puebla FC | 1:1 | ||||
| 7. Round | 07/08/2022 | Deportivo Toluca | - | Club Tijuana | 3:1 | ||||
| 8. Round | 14/08/2022 | Cruz Azul | - | Deportivo Toluca | 2:3 | ||||
| 9. Round | 18/08/2022 | Deportivo Toluca | - | CF Monterrey | 1:1 | |
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| 10. Round | 21/08/2022 | Atlético San Luis | - | Deportivo Toluca | 1:0 | ||||
| 11. Round | 28/08/2022 | Deportivo Toluca | - | CF Pachuca | 1:4 | ||||
| 12. Round | 04/09/2022 | Deportivo Toluca | - | Deportivo Guadalajara | 0:0 | ||||
| 13. Round | 08/09/2022 | UANL Tigres | - | Deportivo Toluca | 3:1 | |
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| 14. Round | 11/09/2022 | Deportivo Toluca | - | Pumas UNAM | 2:2 | |
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| 15. Round | 17/09/2022 | Mazatlán FC | - | Deportivo Toluca | 1:1 | ||||
| 17. Round | 02/10/2022 | Deportivo Toluca | - | Gallos Blancos | 4:1 | |
Uruguay