1. Round | 17/07/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
3. Round | 24/07/2022 | General Caballero DJLM | - | Libertad | 3:2 | ||||
4. Round | 29/07/2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
5. Round | 06/08/2022 | General Caballero DJLM | - | Tacuary | 0:4 | ||||
6. Round | 15/08/2022 | Sportivo Ameliano | - | General Caballero DJLM | 2:0 | ||||
7. Round | 20/08/2022 | General Caballero DJLM | - | Club Olimpia | 0:2 | ||||
8. Round | 27/08/2022 | General Caballero DJLM | - | Cerro Porteño | 1:1 | ||||
9. Round | 03/09/2022 | Resistencia SC | - | General Caballero DJLM | 0:0 | ||||
11. Round | 17/09/2022 | Sol de América | - | General Caballero DJLM | 3:2 | ||||
12. Round | 19/09/2022 | Club Nacional | - | General Caballero DJLM | 1:0 | ||||
17. Round | 15/10/2022 | General Caballero DJLM | - | Sportivo Ameliano | 2:0 | ||||
18. Round | 22/10/2022 | Club Olimpia | - | General Caballero DJLM | 2:1 | ||||
19. Round | 28/10/2022 | Cerro Porteño | - | General Caballero DJLM | 2:1 | ||||
20. Round | 01/11/2022 | General Caballero DJLM | - | Resistencia SC | 1:0 | ||||
22. Round | 13/11/2022 | General Caballero DJLM | - | Sol de América | 0:0 |