| 2. Round | 01/08/2021 | Santos Laguna [U18] | - | Cruz Azul [U18] | 1:2 | ||||
| 3. Round | 07/08/2021 | UANL Tigres [U18] | - | Santos Laguna [U18] | 0:0 | ||||
| 6. Round | 21/08/2021 | Club León [U18] | - | Santos Laguna [U18] | 3:1 | ||||
| 7. Round | 29/08/2021 | Santos Laguna [U18] | - | FC Juárez [U18] | 0:0 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U18] | - | Santos Laguna [U18] | 3:0 | ||||
| 14. Round | 15/09/2021 | CF América [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 9. Round | 19/09/2021 | Santos Laguna [U18] | - | Puebla FC [U18] | 5:1 | ||||
| 10. Round | 26/09/2021 | Santos Laguna [U18] | - | CF Monterrey [U18] | 2:0 |
Mexico