1. Round | 17/07/2021 | 12 de Octubre de Itauguá | - | Club Nacional | 2:2 | ||||
2. Round | 24/07/2021 | Club Nacional | - | Guaraní | 1:1 | ||||
3. Round | 31/07/2021 | Sportivo Luqueño | - | Club Nacional | 2:1 | ||||
4. Round | 07/08/2021 | Club Nacional | - | Libertad | 1:0 | ||||
6. Round | 21/08/2021 | Club Nacional | - | Guaireña FC | 0:2 | ||||
7. Round | 29/08/2021 | Cerro Porteño | - | Club Nacional | 0:2 | ||||
8. Round | 11/09/2021 | Club Nacional | - | Sol de América | 1:1 | ||||
9. Round | 21/09/2021 | Club Olimpia | - | Club Nacional | 1:2 | ||||
10. Round | 25/09/2021 | Club Nacional | - | 12 de Octubre de Itauguá | 1:1 | ||||
11. Round | 03/10/2021 | Guaraní | - | Club Nacional | 1:1 | ||||
12. Round | 16/10/2021 | Club Nacional | - | Sportivo Luqueño | 0:0 | ||||
13. Round | 25/10/2021 | Libertad | - | Club Nacional | 1:2 | ||||
14. Round | 29/10/2021 | Club Nacional | - | River Plate | 1:1 | ||||
15. Round | 08/11/2021 | Guaireña FC | - | Club Nacional | 0:0 | ||||
16. Round | 21/11/2021 | Club Nacional | - | Cerro Porteño | 1:5 | ||||
17. Round | 26/11/2021 | Sol de América | - | Club Nacional | 3:0 | ||||
18. Round | 05/12/2021 | Club Nacional | - | Club Olimpia | 1:3 |