| 2. Round | 17/01/2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
| 3. Round | 25/01/2021 | Gallos Blancos | - | Pumas UNAM | 2:0 | ||||
| 4. Round | 31/01/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 7. Round | 21/02/2021 | Pumas UNAM | - | Club León | 0:1 | ||||
| 8. Round | 01/03/2021 | Deportivo Guadalajara | - | Pumas UNAM | 2:1 | ||||
| 9. Round | 05/03/2021 | Pumas UNAM | - | Santos Laguna | 1:0 | ||||
| 11. Round | 13/03/2021 | FC Juárez | - | Pumas UNAM | 1:1 |  |
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| 14. Round | 10/04/2021 | Club Necaxa | - | Pumas UNAM | 0:1 | ||||
| 15. Round | 18/04/2021 | Pumas UNAM | - | UANL Tigres | 0:0 |
Mexico