| 3. Round | 04/08/2021 | FK Ryazan | - | FK Sakhalin | 2:0 | ||||
| 4. Round | 07/08/2021 | FK Ryazan | - | Dinamo Vladivostok | 0:2 | ||||
| 8. Round | 04/09/2021 | FK Kaluga | - | FK Ryazan | 0:2 | ||||
| 10. Round | 14/09/2021 | FK Ryazan | - | Sokol Saratov | 0:1 | ||||
| 12. Round | 26/09/2021 | Fakel Voronezh 2 | - | FK Ryazan | 0:3 | ||||
| 13. Round | 30/09/2021 | FK Ryazan | - | Arsenal Tula 2 | 1:0 | ||||
| 14. Round | 04/10/2021 | Salyut Belgorod | - | FK Ryazan | 1:0 | ||||
| 16. Round | 13/10/2021 | Dinamo Vladivostok | - | FK Ryazan | 0:0 | ||||
| 17. Round | 19/10/2021 | FK Ryazan | - | Avangard Kursk | 1:0 | ||||
| 19. Round | 31/10/2021 | Dinamo Bryansk | - | FK Ryazan | 1:1 | ||||
| 22. Round | 14/11/2021 | Sokol Saratov | - | FK Ryazan | 2:1 |
Russia