| 1. Round | 22/08/2021 | VV Hoogland | - | VV Gemert | 2:2 |  |
|||
| 2. Round | 29/08/2021 | RKVV DEM | - | VV Hoogland | 0:0 | ||||
| 3. Round | 05/09/2021 | VV Hoogland | - | RKVV Westlandia | 0:4 | ||||
| 4. Round | 12/09/2021 | Unitas Gorinchem | - | VV Hoogland | 3:1 | |
|||
| 5. Round | 19/09/2021 | VV Hoogland | - | EVV | 0:0 | ||||
| 7. Round | 03/10/2021 | VV Hoogland | - | JOS Watergraafsmeer | 3:1 | |
|||
| 8. Round | 10/10/2021 | HSC'21 | - | VV Hoogland | 4:1 | ||||
| 9. Round | 17/10/2021 | VV Hoogland | - | VV Dongen | 0:1 | ||||
| 15. Round | 20/02/2022 | OSS '20 | - | VV Hoogland | 4:1 |  |
|||
| 17. Round | 16/03/2022 | ADO '20 | - | VV Hoogland | 3:0 | ||||
| 19. Round | 20/03/2022 | VV Hoogland | - | RKVV DEM | 0:1 | ||||
| 20. Round | 27/03/2022 | Blauw Geel '38 | - | VV Hoogland | 5:1 | ||||
| 22. Round | 06/04/2022 | VV Hoogland | - | HVV Hollandia | 0:4 | ||||
| 24. Round | 10/04/2022 | VV Hoogland | - | RKSV Groene Ster | 1:0 | ||||
| 25. Round | 16/04/2022 | USV Hercules | - | VV Hoogland | 1:2 | |
|||
| 27. Round | 24/04/2022 | JOS Watergraafsmeer | - | VV Hoogland | 1:3 | ||||
| 30. Round | 15/05/2022 | VV Hoogland | - | ADO '20 | 1:2 | |
|||
| 33. Round | 29/05/2022 | VV UNA | - | VV Hoogland | 1:1 | |
|||
| 34. Round | 06/06/2022 | VV Hoogland | - | Unitas Gorinchem | 2:1 | |
Netherlands