| 3. Round | 29/01/2022 | Puebla FC | - | Club Tijuana | 3:1 |  |
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| 4. Round | 06/02/2022 | Club Tijuana | - | Pumas UNAM | 1:0 | |
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| 5. Round | 12/02/2022 | Mazatlán FC | - | Club Tijuana | 2:0 | ||||
| 6. Round | 19/02/2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 7. Round | 26/02/2022 | Club Tijuana | - | Atlas Guadalajara | 2:0 | ||||
| 8. Round | 02/03/2022 | Deportivo Toluca | - | Club Tijuana | 1:2 | ||||
| 10. Round | 14/03/2022 | Santos Laguna | - | Club Tijuana | 4:0 |  |
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| 11. Round | 21/03/2022 | Club Tijuana | - | FC Juárez | 1:0 | |
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| 12. Round | 04/04/2022 | UANL Tigres | - | Club Tijuana | 2:0 | ||||
| 9. Round | 07/04/2022 | Club Tijuana | - | Atlético San Luis | 1:1 | |
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| 14. Round | 16/04/2022 | Club Tijuana | - | CF América | 1:3 | |
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| 15. Round | 20/04/2022 | Deportivo Guadalajara | - | Club Tijuana | 2:1 | ||||
| 16. Round | 25/04/2022 | Club Tijuana | - | Gallos Blancos | 2:2 | |
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Argentina
Spain