| 1. Round | 23/07/2021 | FC Juárez [U18] | - | Deportivo Toluca [U18] | 1:2 | ||||
| 2. Round | 01/08/2021 | Deportivo Toluca [U18] | - | UANL Tigres [U18] | 4:0 |  |
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| 3. Round | 06/08/2021 | Club Tijuana [U18] | - | Deportivo Toluca [U18] | 3:0 | ||||
| 4. Round | 14/08/2021 | Cruz Azul [U18] | - | Deportivo Toluca [U18] | 0:0 | ||||
| 5. Round | 17/08/2021 | Deportivo Toluca [U18] | - | Mazatlán FC [U18] | 0:1 | ||||
| 6. Round | 21/08/2021 | Atlas Guadalajara [U18] | - | Deportivo Toluca [U18] | 2:0 |  |
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| 9. Round | 18/09/2021 | Deportivo Toluca [U18] | - | CF América [U18] | 0:1 | ||||
| 11. Round | 22/09/2021 | CF Monterrey [U18] | - | Deportivo Toluca [U18] | 2:3 | ||||
| 12. Round | 03/10/2021 | Deportivo Toluca [U18] | - | Gallos Blancos [U18] | 0:1 | ||||
| 13. Round | 17/10/2021 | Deportivo Guadalajara [U18] | - | Deportivo Toluca [U18] | 2:2 | ||||
| 14. Round | 20/10/2021 | Deportivo Toluca [U18] | - | Club Necaxa [U18] | 2:3 |
Mexico