| 6. Round | 10/09/2021 | Yverdon Sport FC | - | FC Aarau | 1:1 | ||||
| 8. Round | 25/09/2021 | Yverdon Sport FC | - | FC Vaduz | 2:0 | ||||
| 9. Round | 02/10/2021 | FC Winterthur | - | Yverdon Sport FC | 1:0 | ||||
| 10. Round | 16/10/2021 | Yverdon Sport FC | - | FC Wil 1900 | 3:0 | ||||
| 11. Round | 02/11/2021 | Stade Lausanne-Ouchy | - | Yverdon Sport FC | 0:0 | ||||
| 16. Round | 03/12/2021 | Yverdon Sport FC | - | FC Schaffhausen | 2:1 | ||||
| 17. Round | 10/12/2021 | FC Vaduz | - | Yverdon Sport FC | 2:2 | ||||
| 18. Round | 17/12/2021 | Yverdon Sport FC | - | SC Kriens | 2:0 | ||||
| 20. Round | 05/02/2022 | SC Kriens | - | Yverdon Sport FC | 0:3 | ||||
| 21. Round | 12/02/2022 | Yverdon Sport FC | - | Neuchâtel Xamax FCS | 0:0 | ||||
| 23. Round | 25/02/2022 | Yverdon Sport FC | - | FC Thun | 2:2 | ||||
| 30. Round | 18/04/2022 | Yverdon Sport FC | - | FC Schaffhausen | 0:1 |  |
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| 31. Round | 24/04/2022 | Yverdon Sport FC | - | FC Winterthur | 2:2 | ||||
| 32. Round | 30/04/2022 | FC Wil 1900 | - | Yverdon Sport FC | 2:2 | |
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| 34. Round | 10/05/2022 | Neuchâtel Xamax FCS | - | Yverdon Sport FC | 1:1 | ||||
| 35. Round | 14/05/2022 | Yverdon Sport FC | - | SC Kriens | 3:2 | ||||
| 36. Round | 21/05/2022 | FC Thun | - | Yverdon Sport FC | 2:1 |
Switzerland