| 1. Round | 03/07/2022 | Atlético San Luis | - | Club León | 1:2 |  |
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| 2. Round | 10/07/2022 | Club León | - | Pumas UNAM | 3:3 | |
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| 3. Round | 16/07/2022 | Puebla FC | - | Club León | 1:1 | |
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| 4. Round | 21/07/2022 | Deportivo Guadalajara | - | Club León | 0:0 | ||||
| 5. Round | 27/07/2022 | Club León | - | Deportivo Toluca | 0:1 | |
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| 6. Round | 01/08/2022 | Club León | - | CF América | 3:2 | ||||
| 7. Round | 07/08/2022 | CF Monterrey | - | Club León | 5:1 | ||||
| 8. Round | 13/08/2022 | Club León | - | Mazatlán FC | 0:3 | ||||
| 9. Round | 19/08/2022 | Santos Laguna | - | Club León | 2:1 | ||||
| 10. Round | 22/08/2022 | CF Pachuca | - | Club León | 1:0 | ||||
| 11. Round | 29/08/2022 | Club León | - | Atlas Guadalajara | 4:2 | |
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| 12. Round | 03/09/2022 | Club Necaxa | - | Club León | 3:2 | ||||
| 13. Round | 07/09/2022 | Club León | - | FC Juárez | 1:0 | |
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| 14. Round | 11/09/2022 | UANL Tigres | - | Club León | 0:1 | |
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| 16. Round | 16/09/2022 | Cruz Azul | - | Club León | 2:1 | ||||
| 15. Round | 19/09/2022 | Club León | - | Gallos Blancos | 3:1 | |
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| 17. Round | 03/10/2022 | Club León | - | Club Tijuana | 2:2 | |
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