| 5. Round | 26/08/2021 | Vida | - | Victoria | 2:0 | ||||
| 6. Round | 29/08/2021 | Honduras Progreso | - | Vida | 1:1 | ||||
| 7. Round | 05/09/2021 | Vida | - | Real España | 1:0 | ||||
| 13. Round | 10/10/2021 | Lobos UPNFM | - | Vida | 0:0 | ||||
| 14. Round | 17/10/2021 | Vida | - | Olimpia | 2:1 |  |
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| 16. Round | 28/10/2021 | Vida | - | Motagua | 1:1 | ||||
| 17. Round | 31/10/2021 | Vida | - | Platense | 3:1 | ||||
| 18. Round | 10/11/2021 | Real España | - | Vida | 2:1 |
Argentina