| 1. Round | 08/01/2018 | Santos Laguna | - | Lobos BUAP | 4:2 | ||||
| 2. Round | 13/01/2018 | Lobos BUAP | - | Gallos Blancos | 0:2 | ||||
| 3. Round | 21/01/2018 | CF Pachuca | - | Lobos BUAP | 3:1 | ||||
| 12. Round | 18/03/2018 | Club León | - | Lobos BUAP | 2:2 | ||||
| 13. Round | 01/04/2018 | Lobos BUAP | - | Deportivo Toluca | 1:2 | ||||
| 14. Round | 07/04/2018 | Cruz Azul | - | Lobos BUAP | 1:0 |
Uruguay