| 1. Round | 22/08/2010 | Liverpool | - | Rampla Juniors | 3:1 |  |
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| 2. Round | 29/08/2010 | Rampla Juniors | - | River Plate | 0:1 | ||||
| 3. Round | 04/09/2010 | Bella Vista | - | Rampla Juniors | 3:2 | ||||
| 4. Round | 19/09/2010 | Rampla Juniors | - | CA Cerro | 0:0 | ||||
| 5. Round | 26/09/2010 | Montevideo Wanderers | - | Rampla Juniors | 2:0 | ||||
| 6. Round | 03/10/2010 | Rampla Juniors | - | Fénix | 2:2 | ||||
| 7. Round | 10/10/2010 | El Tanque Sisley | - | Rampla Juniors | 3:2 | |
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| 8. Round | 17/10/2010 | Rampla Juniors | - | Central Español | 2:2 | ||||
| 9. Round | 24/10/2010 | Defensor Sporting | - | Rampla Juniors | 4:1 |  |
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| 11. Round | 06/11/2010 | Peñarol | - | Rampla Juniors | 1:1 | ||||
| 12. Round | 13/11/2010 | Rampla Juniors | - | Tacuarembó | 1:0 | ||||
| 13. Round | 20/11/2010 | Rampla Juniors | - | Racing | 1:1 | ||||
| 14. Round | 28/11/2010 | Danubio | - | Rampla Juniors | 3:3 | ||||
| 15. Round | 05/12/2010 | Rampla Juniors | - | Nacional | 1:2 |
Uruguay