| 1. Round | 17/07/2021 | Pumas UNAM [Women] | - | Club Necaxa [Women] | 0:0 | ||||
| 4. Round | 07/08/2021 | Cruz Azul [Women] | - | Pumas UNAM [Women] | 1:1 | ||||
| 5. Round | 16/08/2021 | Pumas UNAM [Women] | - | Club Tijuana [Women] | 1:2 | ||||
| 6. Round | 22/08/2021 | Atlas Guadalajara [Women] | - | Pumas UNAM [Women] | 0:0 | ||||
| 7. Round | 28/08/2021 | Pumas UNAM [Women] | - | Gallos Blancos [Women] | 2:0 | ||||
| 9. Round | 14/09/2021 | Club León [Women] | - | Pumas UNAM [Women] | 0:0 | ||||
| 10. Round | 28/09/2021 | Pumas UNAM [Women] | - | FC Juárez [Women] | 3:0 | ||||
| 14. Round | 30/10/2021 | Pumas UNAM [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 16. Round | 13/11/2021 | Pumas UNAM [Women] | - | Puebla FC [Women] | 0:1 | ||||
| 17. Round | 20/11/2021 | Pumas UNAM [Women] | - | Mazatlán FC [Women] | 4:0 |
Mexico