| 1. Round | 07/08/2021 | FC Black Stars Basel | - | FC Basel 1893 II | 3:2 |  |
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| 3. Round | 21/08/2021 | FC Black Stars Basel | - | Etoile Carouge FC | 0:0 | |
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| 4. Round | 28/08/2021 | FC Zürich II | - | FC Black Stars Basel | 0:2 |  |
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| 5. Round | 04/09/2021 | FC Black Stars Basel | - | FC Breitenrain Bern | 1:2 | ||||
| 6. Round | 11/09/2021 | SC Brühl | - | FC Black Stars Basel | 1:3 | ||||
| 10. Round | 09/10/2021 | FC Black Stars Basel | - | FC Bavois | 3:2 | |
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| 11. Round | 16/10/2021 | FC Stade Nyonnais | - | FC Black Stars Basel | 5:0 | ||||
| 13. Round | 30/10/2021 | BSC Young Boys II | - | FC Black Stars Basel | 4:3 | ||||
| 14. Round | 06/11/2021 | FC Black Stars Basel | - | FC Chiasso | 0:3 | ||||
| 15. Round | 13/11/2021 | FC Biel/Bienne | - | FC Black Stars Basel | 1:3 | ||||
| 16. Round | 20/11/2021 | FC Basel 1893 II | - | FC Black Stars Basel | 0:1 |
Switzerland