| 1. Round | 13/02/2022 | Rio Ave FC [Youth] | - | GD Estoril [Youth] | 0:1 | ||||
| 2. Round | 19/02/2022 | FC Alverca [Youth] | - | Rio Ave FC [Youth] | 1:0 | ||||
| 3. Round | 26/02/2022 | Rio Ave FC [Youth] | - | Sporting Braga [Youth] | 0:1 | ||||
| 4. Round | 05/03/2022 | FC Porto [Youth] | - | Rio Ave FC [Youth] | 1:1 | ||||
| 5. Round | 13/03/2022 | Rio Ave FC [Youth] | - | SL Benfica [Youth] | 3:3 | ||||
| 7. Round | 09/04/2022 | Rio Ave FC [Youth] | - | Vitória Guimarães [Youth] | 3:3 | ||||
| 8. Round | 16/04/2022 | GD Estoril [Youth] | - | Rio Ave FC [Youth] | 4:1 | ||||
| 10. Round | 30/04/2022 | Sporting Braga [Youth] | - | Rio Ave FC [Youth] | 2:1 | ||||
| 11. Round | 07/05/2022 | Rio Ave FC [Youth] | - | FC Porto [Youth] | 0:3 | ||||
| 12. Round | 13/05/2022 | SL Benfica [Youth] | - | Rio Ave FC [Youth] | 4:0 |
Portugal