| 1. Round | 16/07/2022 | Tacuary | - | Guaireña FC | 0:0 | ||||
| 2. Round | 21/07/2022 | Tacuary | - | Cerro Porteño | 0:1 | ||||
| 3. Round | 23/07/2022 | Sportivo Ameliano | - | Tacuary | 2:0 | ||||
| 4. Round | 31/07/2022 | Tacuary | - | Club Olimpia | 2:1 |  |
|||
| 5. Round | 06/08/2022 | General Caballero DJLM | - | Tacuary | 0:4 | ||||
| 6. Round | 15/08/2022 | Tacuary | - | Resistencia SC | 1:1 | ||||
| 7. Round | 20/08/2022 | 12 de Octubre de Itauguá | - | Tacuary | 0:2 | ||||
| 8. Round | 28/08/2022 | Tacuary | - | Sol de América | 1:0 | ||||
| 9. Round | 03/09/2022 | Club Nacional | - | Tacuary | 1:0 | ||||
| 10. Round | 11/09/2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 13. Round | 25/09/2022 | Cerro Porteño | - | Tacuary | 5:0 | ||||
| 14. Round | 02/10/2022 | Tacuary | - | Sportivo Ameliano | 1:1 | ||||
| 17. Round | 15/10/2022 | Resistencia SC | - | Tacuary | 0:3 | |
|||
| 18. Round | 21/10/2022 | Tacuary | - | 12 de Octubre de Itauguá | 5:1 | ||||
| 19. Round | 25/10/2022 | Sol de América | - | Tacuary | 2:2 | ||||
| 20. Round | 31/10/2022 | Tacuary | - | Club Nacional | 2:1 | |
|||
| 21. Round | 06/11/2022 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Round | 12/11/2022 | Tacuary | - | Libertad | 1:0 | |
Paraguay