| 1. Round | 11/01/2021 | CF Pachuca [U20] | - | FC Juárez [U20] | 2:0 |  |
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| 2. Round | 18/01/2021 | Club León [U20] | - | CF Pachuca [U20] | 0:3 | ||||
| 4. Round | 29/01/2021 | Mazatlán FC [U20] | - | CF Pachuca [U20] | 1:3 | |
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| 5. Round | 04/02/2021 | Gallos Blancos [U20] | - | CF Pachuca [U20] | 1:2 | ||||
| 6. Round | 15/02/2021 | CF Pachuca [U20] | - | Atlas Guadalajara [U20] | 3:0 | ||||
| 7. Round | 22/02/2021 | CF Pachuca [U20] | - | Deportivo Guadalajara [U20] | 3:2 | ||||
| 8. Round | 27/02/2021 | CF América [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 9. Round | 04/03/2021 | Club Necaxa [U20] | - | CF Pachuca [U20] | 1:1 | |
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| 11. Round | 14/03/2021 | Deportivo Toluca [U20] | - | CF Pachuca [U20] | 2:1 | ||||
| 13. Round | 04/04/2021 | Pumas UNAM [U20] | - | CF Pachuca [U20] | 4:4 | ||||
| 3. Round | 07/04/2021 | CF Pachuca [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 14. Round | 12/04/2021 | CF Pachuca [U20] | - | Puebla FC [U20] | 5:2 | |
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| 15. Round | 18/04/2021 | CF Monterrey [U20] | - | CF Pachuca [U20] | 2:1 | ||||
| 16. Round | 26/04/2021 | CF Pachuca [U20] | - | Santos Laguna [U20] | 3:1 |
Mexico