| 1. Round | 24/07/2021 | CF Pachuca [U20] | - | Club León [U20] | 0:1 | ||||
| 2. Round | 31/07/2021 | Club León [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 3. Round | 05/08/2021 | Gallos Blancos [U20] | - | Club León [U20] | 1:0 |  |
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| 9. Round | 18/09/2021 | Club León [U20] | - | FC Juárez [U20] | 2:0 | |
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| 10. Round | 25/09/2021 | Atlas Guadalajara [U20] | - | Club León [U20] | 2:1 | ||||
| 12. Round | 02/10/2021 | Club León [U20] | - | Atlético San Luis [U20] | 2:0 | ||||
| 13. Round | 16/10/2021 | CF Monterrey [U20] | - | Club León [U20] | 1:1 | ||||
| 14. Round | 20/10/2021 | Club León [U20] | - | Pumas UNAM [U20] | 0:2 | |
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| 16. Round | 31/10/2021 | Deportivo Toluca [U20] | - | Club León [U20] | 1:0 | ||||
| 17. Round | 06/11/2021 | Club León [U20] | - | Club Necaxa [U20] | 3:1 |
Mexico