| 1. Round | 26/07/2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 1:1 | ||||
| 2. Round | 30/07/2021 | Mazatlán FC [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 3. Round | 06/08/2021 | Mazatlán FC [U20] | - | CF Monterrey [U20] | 1:4 | ||||
| 5. Round | 17/08/2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 7. Round | 27/08/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 3:1 |  |
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| 8. Round | 11/09/2021 | CF América [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 9. Round | 18/09/2021 | Mazatlán FC [U20] | - | Pumas UNAM [U20] | 2:1 |  |
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| 10. Round | 24/09/2021 | Club Tijuana [U20] | - | Mazatlán FC [U20] | 3:5 | |
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| 11. Round | 28/09/2021 | Mazatlán FC [U20] | - | FC Juárez [U20] | 2:2 | ||||
| 12. Round | 02/10/2021 | Santos Laguna [U20] | - | Mazatlán FC [U20] | 4:2 | ||||
| 13. Round | 15/10/2021 | Mazatlán FC [U20] | - | Atlas Guadalajara [U20] | 3:1 | |
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| 14. Round | 19/10/2021 | Puebla FC [U20] | - | Mazatlán FC [U20] | 2:1 | ||||
| 15. Round | 22/10/2021 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 4:0 | ||||
| 16. Round | 29/10/2021 | Club Necaxa [U20] | - | Mazatlán FC [U20] | 1:1 | ||||
| 17. Round | 05/11/2021 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 1:0 |
Mexico