| 1. Round | 09/01/2021 | CF América [U20] | - | Atlético San Luis [U20] | 4:1 |  |
|||
| 2. Round | 16/01/2021 | CF Monterrey [U20] | - | CF América [U20] | 2:1 | |
|||
| 7. Round | 20/02/2021 | Atlas Guadalajara [U20] | - | CF América [U20] | 2:1 | ||||
| 8. Round | 27/02/2021 | CF América [U20] | - | CF Pachuca [U20] | 1:1 | ||||
| 9. Round | 03/03/2021 | Club Tijuana [U20] | - | CF América [U20] | 0:1 | ||||
| 10. Round | 06/03/2021 | CF América [U20] | - | Club León [U20] | 0:1 | ||||
| 11. Round | 14/03/2021 | Deportivo Guadalajara [U20] | - | CF América [U20] | 1:1 | ||||
| 12. Round | 19/03/2021 | Mazatlán FC [U20] | - | CF América [U20] | 1:0 | ||||
| 13. Round | 03/04/2021 | CF América [U20] | - | Club Necaxa [U20] | 1:0 |  |
|||
| 14. Round | 10/04/2021 | UANL Tigres [U20] | - | CF América [U20] | 1:2 | |
|||
| 15. Round | 17/04/2021 | CF América [U20] | - | Cruz Azul [U20] | 4:1 | |
|||
| 16. Round | 25/04/2021 | Deportivo Toluca [U20] | - | CF América [U20] | 0:2 | ||||
| 17. Round | 01/05/2021 | Pumas UNAM [U20] | - | CF América [U20] | 0:1 |
Mexico