| 1. Round | 03/07/2022 | Atlético San Luis | - | Club León | 1:2 | ||||
| 2. Round | 10/07/2022 | Deportivo Guadalajara | - | Atlético San Luis | 0:1 | ||||
| 3. Round | 17/07/2022 | Atlético San Luis | - | CF Monterrey | 0:1 | ||||
| 4. Round | 23/07/2022 | Mazatlán FC | - | Atlético San Luis | 1:1 | ||||
| 5. Round | 27/07/2022 | Atlético San Luis | - | Cruz Azul | 0:0 | ||||
| 8. Round | 12/08/2022 | Gallos Blancos | - | Atlético San Luis | 1:1 | ||||
| 9. Round | 19/08/2022 | Atlético San Luis | - | Pumas UNAM | 3:2 | ||||
| 10. Round | 21/08/2022 | Atlético San Luis | - | Deportivo Toluca | 1:0 | ||||
| 11. Round | 29/08/2022 | Santos Laguna | - | Atlético San Luis | 4:1 | ||||
| 12. Round | 02/09/2022 | Atlético San Luis | - | Club Tijuana | 0:0 | ||||
| 13. Round | 07/09/2022 | CF América | - | Atlético San Luis | 3:0 |  |
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| 14. Round | 12/09/2022 | Atlas Guadalajara | - | Atlético San Luis | 1:3 | ||||
| 15. Round | 19/09/2022 | Atlético San Luis | - | CF Pachuca | 1:2 | ||||
| 17. Round | 01/10/2022 | Atlético San Luis | - | UANL Tigres | 0:3 |
Ecuador