| 1. Round | 02/07/2022 | Deportivo Guadalajara | - | FC Juárez | 0:0 | ||||
| 3. Round | 17/07/2022 | Santos Laguna | - | Deportivo Guadalajara | 1:1 |  |
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| 4. Round | 21/07/2022 | Deportivo Guadalajara | - | Club León | 0:0 |  |
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| 6. Round | 31/07/2022 | Deportivo Guadalajara | - | CF Pachuca | 0:0 | ||||
| 7. Round | 06/08/2022 | Mazatlán FC | - | Deportivo Guadalajara | 2:1 | |
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| 8. Round | 14/08/2022 | Deportivo Guadalajara | - | Atlas Guadalajara | 1:1 | ||||
| 10. Round | 20/08/2022 | Club Necaxa | - | Deportivo Guadalajara | 0:4 | ||||
| 16. Round | 24/08/2022 | Deportivo Guadalajara | - | CF Monterrey | 1:0 | ||||
| 11. Round | 28/08/2022 | Deportivo Guadalajara | - | Pumas UNAM | 3:1 | ||||
| 12. Round | 04/09/2022 | Deportivo Toluca | - | Deportivo Guadalajara | 0:0 | ||||
| 13. Round | 08/09/2022 | Club Tijuana | - | Deportivo Guadalajara | 1:2 |  |
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| 14. Round | 11/09/2022 | Deportivo Guadalajara | - | Puebla FC | 1:0 | ||||
| 9. Round | 14/09/2022 | Deportivo Guadalajara | - | UANL Tigres | 1:4 | ||||
| 15. Round | 18/09/2022 | CF América | - | Deportivo Guadalajara | 2:1 | ||||
| 17. Round | 02/10/2022 | Cruz Azul | - | Deportivo Guadalajara | 2:1 |
Mexico