| 1. Round | 03/07/2022 | CF América | - | Atlas Guadalajara | 0:0 | ||||
| 2. Round | 10/07/2022 | Deportivo Toluca | - | Atlas Guadalajara | 3:2 | ||||
| 3. Round | 16/07/2022 | Atlas Guadalajara | - | Cruz Azul | 3:2 | ||||
| 4. Round | 24/07/2022 | UANL Tigres | - | Atlas Guadalajara | 2:0 | ||||
| 5. Round | 27/07/2022 | Atlas Guadalajara | - | Club Tijuana | 1:2 |  |
|||
| 6. Round | 01/08/2022 | Santos Laguna | - | Atlas Guadalajara | 1:0 | ||||
| 7. Round | 05/08/2022 | Atlas Guadalajara | - | Gallos Blancos | 3:1 |  |
|||
| 8. Round | 14/08/2022 | Deportivo Guadalajara | - | Atlas Guadalajara | 1:1 |  |
|||
| 10. Round | 21/08/2022 | Atlas Guadalajara | - | Puebla FC | 1:1 | ||||
| 16. Round | 26/08/2022 | CF Pachuca | - | Atlas Guadalajara | 3:1 | ||||
| 11. Round | 29/08/2022 | Club León | - | Atlas Guadalajara | 4:2 | ||||
| 12. Round | 04/09/2022 | Atlas Guadalajara | - | Pumas UNAM | 0:0 | ||||
| 13. Round | 08/09/2022 | Mazatlán FC | - | Atlas Guadalajara | 1:0 | ||||
| 15. Round | 18/09/2022 | CF Monterrey | - | Atlas Guadalajara | 2:0 | ||||
| 17. Round | 02/10/2022 | Atlas Guadalajara | - | Club Necaxa | 1:0 |
Mexico