| 1. Round | 18/09/2021 | Leones Negros II | - | Gavilanes de Matamoros | 2:2 | ||||
| 2. Round | 25/09/2021 | Mazorqueros | - | Leones Negros II | 3:0 | ||||
| 3. Round | 02/10/2021 | Leones Negros II | - | Tecos Fútbol Club | 0:0 | ||||
| 4. Round | 10/10/2021 | Colima FC | - | Leones Negros II | 2:1 |  |
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| 5. Round | 13/10/2021 | Correcaminos UAT II | - | Leones Negros II | 1:1 | ||||
| 6. Round | 16/10/2021 | Leones Negros II | - | Coras de Nayarit | 2:0 | ||||
| 7. Round | 23/10/2021 | Mineros de Fresnillo FC | - | Leones Negros II | 0:3 | ||||
| 8. Round | 30/10/2021 | Leones Negros II | - | Tuzos de la UAZ | 1:0 | ||||
| 9. Round | 06/11/2021 | Alacranes de Durango | - | Leones Negros II | 2:1 | |
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| 10. Round | 10/11/2021 | Leones Negros II | - | Cimarrones de Sonora II | 1:2 | |
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| 11. Round | 13/11/2021 | Saltillo FC | - | Leones Negros II | 3:1 | |
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| 12. Round | 20/11/2021 | Leones Negros II | - | Tritones Vallarta | 3:3 | ||||
| 13. Round | 27/11/2021 | Catedráticos Elite | - | Leones Negros II | 3:2 | |
Mexico