| 2. Round | 08/08/2021 | Atlante | - | CF Monterrey II | 2:1 | ||||
| 5. Round | 26/08/2021 | CF Monterrey II | - | Club Celaya | 1:0 | ||||
| 6. Round | 01/09/2021 | Alebrijes de Oaxaca | - | CF Monterrey II | 0:0 |  |
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| 7. Round | 08/09/2021 | CF Monterrey II | - | TM Fútbol Club | 0:0 | ||||
| 8. Round | 16/09/2021 | Cimarrones de Sonora | - | CF Monterrey II | 1:2 | |
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| 9. Round | 21/09/2021 | CF Monterrey II | - | Mineros de Zacatecas | 0:1 | ||||
| 10. Round | 28/09/2021 | Tepatitlán | - | CF Monterrey II | 1:1 | |
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| 11. Round | 06/10/2021 | CF Monterrey II | - | Coyotes de Tlaxcala | 4:1 | ||||
| 17. Round | 16/11/2021 | CF Monterrey II | - | Atlético Morelia | 0:1 |
Mexico