| 2. Round | 15/01/2021 | Club Necaxa [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 3. Round | 21/01/2021 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 3:2 | ||||
| 6. Round | 12/02/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 1:0 | ||||
| 8. Round | 25/02/2021 | Atlético San Luis [U20] | - | UANL Tigres [U20] | 2:1 | ||||
| 11. Round | 14/03/2021 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 12. Round | 20/03/2021 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 4. Round | 26/03/2021 | Club León [U20] | - | Atlético San Luis [U20] | 4:2 | ||||
| 13. Round | 03/04/2021 | CF Monterrey [U20] | - | Atlético San Luis [U20] | 4:1 | ||||
| 14. Round | 09/04/2021 | FC Juárez [U20] | - | Atlético San Luis [U20] | 2:2 | ||||
| 16. Round | 24/04/2021 | Cruz Azul [U20] | - | Atlético San Luis [U20] | 0:1 |
Mexico