| 1. Round | 19/03/2022 | OFI Heraklion | - | Ionikos Nikea | 2:3 |  |
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| 2. Round | 02/04/2022 | Lamia | - | OFI Heraklion | 1:2 | |
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| 3. Round | 09/04/2022 | OFI Heraklion | - | Apollon Smyrnis | 1:2 | |
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| 4. Round | 17/04/2022 | Atromitos | - | OFI Heraklion | 1:1 | |
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| 5. Round | 30/04/2022 | OFI Heraklion | - | Panetolikos | 0:1 | ||||
| 6. Round | 08/05/2022 | OFI Heraklion | - | Asteras Tripolis | 1:0 | |
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| 7. Round | 14/05/2022 | Volos NFC | - | OFI Heraklion | 5:0 |
Brazil