| 20. Round | 04/02/2022 | Neuchâtel Xamax FCS | - | FC Schaffhausen | 2:1 | ||||
| 21. Round | 11/02/2022 | FC Schaffhausen | - | FC Vaduz | 4:2 | ||||
| 22. Round | 19/02/2022 | FC Wil 1900 | - | FC Schaffhausen | 3:2 | ||||
| 19. Round | 22/02/2022 | FC Schaffhausen | - | FC Thun | 1:0 |  |
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| 23. Round | 25/02/2022 | FC Schaffhausen | - | FC Winterthur | 3:2 | ||||
| 24. Round | 01/03/2022 | FC Schaffhausen | - | Stade Lausanne-Ouchy | 0:1 | |
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| 26. Round | 11/03/2022 | FC Schaffhausen | - | Yverdon Sport FC | 3:1 | ||||
| 27. Round | 19/03/2022 | SC Kriens | - | FC Schaffhausen | 0:0 | ||||
| 28. Round | 01/04/2022 | FC Schaffhausen | - | Neuchâtel Xamax FCS | 2:1 | ||||
| 29. Round | 10/04/2022 | FC Vaduz | - | FC Schaffhausen | 2:3 | ||||
| 30. Round | 18/04/2022 | Yverdon Sport FC | - | FC Schaffhausen | 0:1 | ||||
| 31. Round | 22/04/2022 | FC Schaffhausen | - | FC Wil 1900 | 5:2 | ||||
| 32. Round | 29/04/2022 | FC Winterthur | - | FC Schaffhausen | 1:1 | ||||
| 33. Round | 06/05/2022 | FC Schaffhausen | - | SC Kriens | 4:1 | ||||
| 34. Round | 10/05/2022 | FC Thun | - | FC Schaffhausen | 2:5 | ||||
| 35. Round | 14/05/2022 | FC Schaffhausen | - | FC Aarau | 0:1 | ||||
| 36. Round | 21/05/2022 | Stade Lausanne-Ouchy | - | FC Schaffhausen | 1:2 |
Austria