| 1. Round | 17/07/2010 | 1. FC Slovácko | - | FK Teplice | 3:0 | ||||
| 3. Round | 01/08/2010 | FK Baumit Jablonec | - | FK Teplice | 1:1 | ||||
| 4. Round | 09/08/2010 | FK Teplice | - | Dynamo České Budějovice | 1:1 | ||||
| 5. Round | 16/08/2010 | FK Ústí nad Labem | - | FK Teplice | 0:2 | ||||
| 6. Round | 23/08/2010 | FK Teplice | - | Slavia Praha | 2:1 | ||||
| 7. Round | 28/08/2010 | Baník Ostrava | - | FK Teplice | 0:1 | ||||
| 9. Round | 19/09/2010 | FK Mladá Boleslav | - | FK Teplice | 3:3 | ||||
| 10. Round | 27/09/2010 | FK Teplice | - | Sigma Olomouc | 1:0 | ||||
| 11. Round | 02/10/2010 | FK Teplice | - | Slovan Liberec | 1:0 | ||||
| 13. Round | 22/10/2010 | FK Teplice | - | FC Hradec Králové | 2:1 |  |
|||
| 14. Round | 29/10/2010 | Viktoria Plzeň | - | FK Teplice | 4:2 | ||||
| 15. Round | 07/11/2010 | FK Teplice | - | Bohemians 1905 | 0:2 | ||||
| 16. Round | 14/11/2010 | 1. FK Příbram | - | FK Teplice | 1:1 | ||||
| 17. Round | 22/11/2010 | FK Teplice | - | FK Baumit Jablonec | 1:2 |
Czech Republic