| 9. Round | 11/09/2021 | Avangard Kursk | - | Dinamo Vladivostok | 1:2 | ||||
| 10. Round | 14/09/2021 | Avangard Kursk | - | FK Sakhalin | 2:0 | ||||
| 12. Round | 26/09/2021 | Avangard Kursk | - | Dinamo Bryansk | 4:4 | ||||
| 13. Round | 30/09/2021 | FK Kaluga | - | Avangard Kursk | 2:1 | ||||
| 14. Round | 04/10/2021 | Arsenal Tula 2 | - | Avangard Kursk | 0:2 | ||||
| 16. Round | 14/10/2021 | Avangard Kursk | - | Sokol Saratov | 0:0 | ||||
| 17. Round | 19/10/2021 | FK Ryazan | - | Avangard Kursk | 1:0 | ||||
| 18. Round | 25/10/2021 | Avangard Kursk | - | Fakel Voronezh 2 | 1:1 | ||||
| 19. Round | 31/10/2021 | Avangard Kursk | - | Salyut Belgorod | 1:0 | ||||
| 22. Round | 14/11/2021 | FK Sakhalin | - | Avangard Kursk | 0:3 |  |
Russia