| 4. Round | 28/08/2021 | AS Saint-Priest | - | Olympique Lyonnais B | 1:3 | ||||
| 6. Round | 11/09/2021 | GOAL FC | - | Olympique Lyonnais B | 2:0 | ||||
| 7. Round | 18/09/2021 | Olympique Lyonnais B | - | Aubagne FC | 3:1 | ||||
| 8. Round | 25/09/2021 | Jura Sud | - | Olympique Lyonnais B | 1:1 | ||||
| 10. Round | 23/10/2021 | Marignane Gignac FC | - | Olympique Lyonnais B | 4:0 | ||||
| 11. Round | 06/11/2021 | Olympique Lyonnais B | - | SC Toulon | 0:0 |  |
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| 17. Round | 05/02/2022 | GFA Rumilly Vallières | - | Olympique Lyonnais B | 0:0 | ||||
| 18. Round | 12/02/2022 | Olympique Lyonnais B | - | AS Saint-Priest | 0:0 | ||||
| 21. Round | 12/03/2022 | Aubagne FC | - | Olympique Lyonnais B | 3:0 | |
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| 24. Round | 09/04/2022 | Olympique Lyonnais B | - | Marignane Gignac FC | 3:1 | ||||
| 25. Round | 16/04/2022 | SC Toulon | - | Olympique Lyonnais B | 2:1 | ||||
| 26. Round | 23/04/2022 | RC Grasse | - | Olympique Lyonnais B | 2:1 | ||||
| 28. Round | 14/05/2022 | Hyères FC | - | Olympique Lyonnais B | 1:1 |
France