| 1. Round | 15/08/2021 | Sporting Gijón | - | Burgos CF | 1:0 | ||||
| 2. Round | 21/08/2021 | CD Tenerife | - | Sporting Gijón | 0:0 | ||||
| 3. Round | 28/08/2021 | Sporting Gijón | - | CD Mirandés | 2:1 |  |
|||
| 4. Round | 03/09/2021 | Girona FC | - | Sporting Gijón | 1:2 |  |
|||
| 5. Round | 10/09/2021 | Sporting Gijón | - | CD Leganés | 2:1 | ||||
| 6. Round | 19/09/2021 | SD Eibar | - | Sporting Gijón | 3:2 | ||||
| 7. Round | 26/09/2021 | Sporting Gijón | - | Málaga CF | 2:1 | ||||
| 9. Round | 09/10/2021 | Real Oviedo | - | Sporting Gijón | 1:1 | ||||
| 11. Round | 19/10/2021 | FC Cartagena | - | Sporting Gijón | 1:0 | ||||
| 12. Round | 23/10/2021 | Sporting Gijón | - | Real Valladolid | 1:2 | |
|||
| 13. Round | 30/10/2021 | CD Lugo | - | Sporting Gijón | 1:1 | ||||
| 16. Round | 12/11/2021 | Sporting Gijón | - | Real Sociedad B | 0:1 | ||||
| 21. Round | 18/12/2021 | UD Ibiza | - | Sporting Gijón | 0:2 | ||||
| 26. Round | 05/02/2022 | Sporting Gijón | - | SD Eibar | 0:1 | ||||
| 27. Round | 12/02/2022 | CD Mirandés | - | Sporting Gijón | 0:3 | ||||
| 28. Round | 20/02/2022 | Sporting Gijón | - | SD Ponferradina | 2:3 |
Spain