| 1. Round | 09/01/2022 | Cruz Azul | - | Club Tijuana | 2:0 | ||||
| 2. Round | 16/01/2022 | Club Tijuana | - | Club León | 1:1 | ||||
| 3. Round | 29/01/2022 | Puebla FC | - | Club Tijuana | 3:1 |  |
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| 4. Round | 06/02/2022 | Club Tijuana | - | Pumas UNAM | 1:0 | ||||
| 5. Round | 12/02/2022 | Mazatlán FC | - | Club Tijuana | 2:0 | ||||
| 6. Round | 19/02/2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 7. Round | 26/02/2022 | Club Tijuana | - | Atlas Guadalajara | 2:0 |  |
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| 8. Round | 02/03/2022 | Deportivo Toluca | - | Club Tijuana | 1:2 | |
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| 10. Round | 14/03/2022 | Santos Laguna | - | Club Tijuana | 4:0 | ||||
| 11. Round | 21/03/2022 | Club Tijuana | - | FC Juárez | 1:0 | ||||
| 12. Round | 04/04/2022 | UANL Tigres | - | Club Tijuana | 2:0 | ||||
| 9. Round | 07/04/2022 | Club Tijuana | - | Atlético San Luis | 1:1 | ||||
| 13. Round | 12/04/2022 | CF Pachuca | - | Club Tijuana | 0:0 | ||||
| 14. Round | 16/04/2022 | Club Tijuana | - | CF América | 1:3 | ||||
| 15. Round | 20/04/2022 | Deportivo Guadalajara | - | Club Tijuana | 2:1 | ||||
| 16. Round | 25/04/2022 | Club Tijuana | - | Gallos Blancos | 2:2 | |
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| 17. Round | 01/05/2022 | CF Monterrey | - | Club Tijuana | 2:0 |
Mexico