| Round of 16 | 30/06/2022 | Independiente del Valle | - | Lanús | 2:1 | ||||
| Round of 16 | 07/07/2022 | Lanús | - | Independiente del Valle | 0:0 | ||||
| Quarter-finals | 03/08/2022 | Deportivo Táchira | - | Independiente del Valle | 0:1 |  |
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| Quarter-finals | 10/08/2022 | Independiente del Valle | - | Deportivo Táchira | 4:1 | ||||
| Semi-finals | 01/09/2022 | Independiente del Valle | - | FBC Melgar | 3:0 | ||||
| Semi-finals | 08/09/2022 | FBC Melgar | - | Independiente del Valle | 0:3 |  |
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| Final | 01/10/2022 | São Paulo FC | - | Independiente del Valle | 0:2 |
Ecuador