1. Round | 24/07/2021 | Macará | - | Guayaquil City | 0:2 | ||||
2. Round | 31/07/2021 | Guayaquil City | - | Deportivo Cuenca | 2:1 | ||||
3. Round | 08/08/2021 | Barcelona | - | Guayaquil City | 2:1 | ||||
4. Round | 14/08/2021 | Guayaquil City | - | Delfín SC | 2:1 | ||||
5. Round | 21/08/2021 | Universidad Catolica | - | Guayaquil City | 1:1 | ||||
6. Round | 29/08/2021 | Guayaquil City | - | Técnico Universitario | 1:0 | ||||
7. Round | 18/09/2021 | Orense SC | - | Guayaquil City | 2:0 | ||||
8. Round | 25/09/2021 | Guayaquil City | - | 9 de Octubre | 0:1 | ||||
9. Round | 03/10/2021 | LDU Quito | - | Guayaquil City | 3:1 | ||||
10. Round | 16/10/2021 | Guayaquil City | - | Olmedo | 4:2 | ||||
11. Round | 24/10/2021 | Manta | - | Guayaquil City | 1:1 | ||||
12. Round | 31/10/2021 | Guayaquil City | - | Emelec | 0:1 | ||||
13. Round | 08/11/2021 | Guayaquil City | - | Independiente del Valle | 0:2 | ||||
15. Round | 28/11/2021 | Guayaquil City | - | Aucas | 1:0 |