| 1. Round | 11/01/2021 | Club León [Women] | - | Deportivo Toluca [Women] | 0:2 | ||||
| 3. Round | 26/01/2021 | Club León [Women] | - | Club Necaxa [Women] | 2:1 | ||||
| 8. Round | 28/02/2021 | Deportivo Guadalajara [Women] | - | Club León [Women] | 5:1 | ||||
| 9. Round | 09/03/2021 | Club León [Women] | - | Mazatlán FC [Women] | 1:2 | ||||
| 10. Round | 12/03/2021 | Club León [Women] | - | CF Monterrey [Women] | 0:3 | ||||
| 11. Round | 15/03/2021 | CF Pachuca [Women] | - | Club León [Women] | 2:0 |
Mexico