1. Round | 24/07/2021 | KV Oostende | - | Sporting Charleroi | 0:3 | ||||
2. Round | 30/07/2021 | KRC Genk | - | KV Oostende | 3:4 | ||||
3. Round | 08/08/2021 | KV Oostende | - | KAA Gent | 1:0 | ||||
4. Round | 14/08/2021 | RFC Seraing | - | KV Oostende | 2:3 | ||||
5. Round | 20/08/2021 | Standard Liège | - | KV Oostende | 1:0 | ||||
6. Round | 29/08/2021 | KV Oostende | - | SV Zulte Waregem | 0:2 | ||||
7. Round | 10/09/2021 | Club Brugge KV | - | KV Oostende | 3:0 | ||||
8. Round | 18/09/2021 | KV Oostende | - | K Beerschot VA | 3:1 | ||||
9. Round | 26/09/2021 | KV Oostende | - | RSC Anderlecht | 2:2 | ||||
10. Round | 02/10/2021 | Sint-Truidense VV | - | KV Oostende | 1:1 | ||||
11. Round | 16/10/2021 | KV Oostende | - | Cercle Brugge | 2:1 | ||||
12. Round | 23/10/2021 | KV Kortrijk | - | KV Oostende | 1:0 | ||||
13. Round | 29/10/2021 | KV Oostende | - | KV Mechelen | 2:4 | ||||
14. Round | 05/11/2021 | Oud-Heverlee Leuven | - | KV Oostende | 1:0 | ||||
15. Round | 21/11/2021 | KV Oostende | - | Union Saint-Gilloise | 1:7 | ||||
23. Round | 21/01/2022 | KV Oostende | - | Royal Antwerp FC | 1:2 | ||||
25. Round | 29/01/2022 | Cercle Brugge | - | KV Oostende | 0:1 |