1. Round | 08/01/2022 | Puebla FC | - | CF América | 1:1 | ||||
5. Round | 12/02/2022 | Puebla FC | - | Atlas Guadalajara | 1:1 | ||||
9. Round | 06/03/2022 | Cruz Azul | - | Puebla FC | 1:3 | ||||
10. Round | 13/03/2022 | Atlético San Luis | - | Puebla FC | 2:1 | ||||
11. Round | 19/03/2022 | Puebla FC | - | Santos Laguna | 2:2 | ||||
12. Round | 03/04/2022 | Deportivo Toluca | - | Puebla FC | 2:1 | ||||
13. Round | 09/04/2022 | Puebla FC | - | Pumas UNAM | 2:2 | ||||
14. Round | 16/04/2022 | Club León | - | Puebla FC | 0:1 | ||||
15. Round | 20/04/2022 | CF Pachuca | - | Puebla FC | 1:0 | ||||
16. Round | 23/04/2022 | Puebla FC | - | Club Necaxa | 0:1 | ||||
17. Round | 30/04/2022 | Mazatlán FC | - | Puebla FC | 2:1 |