| 1. Round | 03/08/2010 | Defensor Sporting | - | Club Olimpia | 2:0 | ||||
| 1. Round | 03/09/2010 | Club Olimpia | - | Defensor Sporting | 1:1 | ||||
| 2. Round | 17/09/2010 | Defensor Sporting | - | Sport Huancayo | 9:0 | ||||
| 2. Round | 22/09/2010 | Sport Huancayo | - | Defensor Sporting | 2:0 |  |
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| Round of 16 | 29/09/2010 | Defensor Sporting | - | Independiente | 1:0 | ||||
| Round of 16 | 19/10/2010 | Independiente | - | Defensor Sporting | 4:2 | |
Uruguay