| 6. Round | 29/08/2021 | MFK Karviná | - | Slavia Praha | 3:3 | ||||
| 7. Round | 12/09/2021 | FK Jablonec | - | MFK Karviná | 1:0 | ||||
| 9. Round | 25/09/2021 | Dynamo České Budějovice | - | MFK Karviná | 3:1 | ||||
| 10. Round | 03/10/2021 | MFK Karviná | - | FK Mladá Boleslav | 0:1 | ||||
| 11. Round | 17/10/2021 | Sigma Olomouc | - | MFK Karviná | 2:0 | ||||
| 15. Round | 21/11/2021 | MFK Karviná | - | Slovan Liberec | 1:2 | ||||
| 13. Round | 01/12/2021 | Bohemians Praha 1905 | - | MFK Karviná | 3:0 | ||||
| 17. Round | 04/12/2021 | MFK Karviná | - | AC Sparta Praha | 1:2 |  |
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| 18. Round | 11/12/2021 | FC Fastav Zlín | - | MFK Karviná | 2:1 | |
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| 19. Round | 18/12/2021 | MFK Karviná | - | Viktoria Plzeň | 0:1 |
Czech Republic