| 1. Round | 30/07/2022 | FK Třinec | - | MFK Karviná | 0:3 | ||||
| 3. Round | 12/08/2022 | FK Viagem Příbram | - | MFK Karviná | 1:1 | ||||
| 8. Round | 09/09/2022 | MFK Karviná | - | AC Sparta Praha B | 2:0 | ||||
| 9. Round | 17/09/2022 | MFK Chrudim | - | MFK Karviná | 5:1 | ||||
| 10. Round | 01/10/2022 | SK Líšeň | - | MFK Karviná | 1:2 | ||||
| 11. Round | 08/10/2022 | MFK Karviná | - | SFC Opava | 1:0 |  |
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| 12. Round | 15/10/2022 | 1. SK Prostějov | - | MFK Karviná | 2:1 | ||||
| 13. Round | 22/10/2022 | MFK Karviná | - | FK Dukla Praha | 5:0 | ||||
| 14. Round | 30/10/2022 | Slavia Praha B | - | MFK Karviná | 4:2 | ||||
| 15. Round | 04/11/2022 | MFK Karviná | - | FK Varnsdorf | 1:0 | ||||
| 16. Round | 13/11/2022 | FC Sellier & Bellot Vlašim | - | MFK Karviná | 2:1 |
Czech Republic