| 1. Round | 14/08/2021 | SV 19 Straelen | - | Rot Weiss Ahlen | 3:2 | ||||
| 2. Round | 21/08/2021 | Rot Weiss Ahlen | - | Wuppertaler SV | 0:0 | ||||
| 3. Round | 25/08/2021 | Fortuna Köln | - | Rot Weiss Ahlen | 1:1 |  |
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| 4. Round | 28/08/2021 | Rot Weiss Ahlen | - | Fortuna Düsseldorf II | 1:1 | ||||
| 5. Round | 04/09/2021 | VfB Homberg | - | Rot Weiss Ahlen | 1:2 | ||||
| 6. Round | 10/09/2021 | Rot Weiss Ahlen | - | Preußen Münster | 1:1 | ||||
| 12. Round | 15/10/2021 | Rot Weiss Ahlen | - | 1. FC Köln II | 2:6 | |
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| 24. Round | 05/02/2022 | Rot Weiss Ahlen | - | VfB Homberg | 3:3 | ||||
| 26. Round | 13/04/2022 | Rot Weiss Ahlen | - | FC Schalke 04 II | 3:2 | ||||
| 34. Round | 16/04/2022 | Rot Weiss Ahlen | - | Sportfreunde Lotte | 1:1 | ||||
| 35. Round | 23/04/2022 | FC Wegberg-Beeck | - | Rot Weiss Ahlen | 0:1 | ||||
| 32. Round | 27/04/2022 | Rot Weiss Ahlen | - | Alemannia Aachen | 0:2 | ||||
| 36. Round | 30/04/2022 | Rot Weiss Ahlen | - | SV Rödinghausen | 2:1 | ||||
| 37. Round | 07/05/2022 | Rot Weiss Ahlen | - | Bonner SC | 1:1 | ||||
| 38. Round | 14/05/2022 | Rot-Weiss Essen | - | Rot Weiss Ahlen | 2:0 |
Bulgaria