| 1. Round | 16/07/2022 | Spartak Trnava | - | Zlaté Moravce | 2:0 | ||||
| 2. Round | 24/07/2022 | Spartak Trnava | - | Dukla Banská Bystrica | 1:2 | ||||
| 5. Round | 14/08/2022 | MFK Zemplín Michalovce | - | Spartak Trnava | 0:4 | ||||
| 6. Round | 20/08/2022 | Spartak Trnava | - | FC DAC 1904 | 3:1 | ||||
| 7. Round | 27/08/2022 | MFK Skalica | - | Spartak Trnava | 1:1 | ||||
| 8. Round | 31/08/2022 | Spartak Trnava | - | Tatran Liptovský Mikuláš | 1:0 | ||||
| 9. Round | 04/09/2022 | MFK Ružomberok | - | Spartak Trnava | 3:2 | ||||
| 13. Round | 08/10/2022 | Dukla Banská Bystrica | - | Spartak Trnava | 0:2 | ||||
| 14. Round | 16/10/2022 | FK Železiarne Podbrezová | - | Spartak Trnava | 3:1 | ||||
| 15. Round | 22/10/2022 | MŠK Žilina | - | Spartak Trnava | 1:2 |  |
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| 17. Round | 05/11/2022 | FC DAC 1904 | - | Spartak Trnava | 1:0 | ||||
| 18. Round | 11/11/2022 | Spartak Trnava | - | MFK Skalica | 2:1 | ||||
| 16. Round | 24/11/2022 | Spartak Trnava | - | MFK Zemplín Michalovce | 4:1 | ||||
| 21. Round | 25/02/2023 | Spartak Trnava | - | AS Trenčín | 3:2 |
Slovakia